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Article

Lost in translation: implications of HIV-1 codon usage for immune escape and drug resistance.

AIDS reviews - 1 Jan 2000

Kijak Gustavo H, Currier Jeffrey R, Tovanabutra Sodsai, Cox Josephine H, Michael Nelson L, Wegner Scott A, Birx Deborah L, McCutchan Francine E

Abstract excerpt

Synonymous nucleotide substitutions in protein-coding sequences are often regarded as evolutionarily neutral and not subject to selective pressure. However, synonymous codons can sometimes lead to different patterns of amino acid substitution by single nucleotide changes. Based on the deconstruction of the standard genetic code, we propose the term 'quasi-synonymous' to describe codons that specify the same amino...

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PMID: 15168741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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