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Dengue virus preferentially uses human and mosquito non-optimal codons

22 Jul 2024

Abstract excerpt

Codon optimality refers to the effect that codon composition has on messenger RNA (mRNA) stability and translation level and implies that synonymous codons are not silent from a regulatory point of view. Here, we investigated the adaptation of virus genomes to the host optimality code using mosquito-borne dengue virus (DENV) as a model. We demonstrated that codon optimality exists in mosquito cells and showed...

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PMID: 39039212
DOI: 10.1038/s44320-024-00052-7

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