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Article

Ras mediates translation initiation factor 4E-induced malignant transformation.

Genes & development - 1 Sept 1992

Lazaris-Karatzas A, Smith M R, Frederickson R M, Jaramillo M L, Liu Y L, Kung H F, Sonenberg N

Abstract excerpt

Translation initiation factor eIF-4E binds to the eukaryotic mRNA 5' cap structure (m7 GpppN, where N is any nucleotide). eIF-4E is a limiting factor in translation and plays a key role in regulation of translation. We have shown previously that overexpression of eIF-4E in rodent fibroblasts results in tumorigenic transformation. eIF-4E also exhibits mitogenic activity when microinjected into serum-starved...

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Identifiers

PMID: 1516827
DOI: 10.1101/gad.6.9.1631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ras mediates translation initiation factor 4E-induced malignant transformation.PMID 1516827Read ↗

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Eukaryotic initiation factor 4E variants alter the morphology, proliferation, and colony-formation properties of MDA-MB-435 cancer cells.Semantic proximity Read ↗

Expression of antisense RNA against initiation factor eIF-4E mRNA in HeLa cells results in lengthened cell division times, diminished translation rates, and reduced levels of both eIF-4E and the p220 component of eIF-4F.Semantic proximity Read ↗

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