Article
Ras mediates translation initiation factor 4E-induced malignant transformation.
Genes & development - 1 Sept 1992
Lazaris-Karatzas A, Smith M R, Frederickson R M, Jaramillo M L, Liu Y L, Kung H F, Sonenberg N
Abstract excerpt
Translation initiation factor eIF-4E binds to the eukaryotic mRNA 5' cap structure (m7 GpppN, where N is any nucleotide). eIF-4E is a limiting factor in translation and plays a key role in regulation of translation. We have shown previously that overexpression of eIF-4E in rodent fibroblasts resu...
Topics
- 3T3 Cells
- Animals
- Blotting, Northern
- Blotting, Western
- Carcinogenicity Tests
- Cell Transformation, Neoplastic
- Eukaryotic Initiation Factor-4E
- GTPase-Activating Proteins
- Mice
- Mutation
- Peptide Initiation Factors
- Protein Biosynthesis
- Proteins
- Proto-Oncogene Proteins p21(ras)
- Signal Transduction
- ras GTPase-Activating Proteins