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Article

Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation.

The Journal of biological chemistry - 19 Feb 2010

Ly Thi K, Wang Jianbin, Pereira Ryan, Rojas Katherine S, Peng Xu, Feng Qiyu, Cerione Richard A, Wilson Kristin F

Abstract excerpt

Although the small GTPase Ran is best known for its roles in nucleocytoplasmic transport, mitotic spindle assembly, and nuclear envelope formation, recent studies have demonstrated the overexpression of Ran in multiple tumor types and that its expression is correlated with a poor patient prognosis, providing evidence for the importance of this GTPase in cell growth regulation. Here we show that Ran is subject to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20028979
DOI: 10.1074/jbc.M109.071886
PMCID: PMC2820807

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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