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Article

Sensitizing glioma cells to cisplatin by abrogating the p53 response with antisense oligonucleotides.

Cancer gene therapy - 1 Aug 2004

Datta Kamal, Shah Preeti, Srivastava Tapasya, Mathur Srinivas G, Chattopadhyay Parthaprasad, Sinha Subrata

Abstract excerpt

Most gene therapy strategies related to p53 concentrate on the restoration of the activity of mutant p53, as several observations indicate that tumors and cell lines having the mutant gene are resistant to chemotherapy. However, as there is also some evidence to the contrary, we studied the relationship of the p53 status to the cellular response of glioma cells that were exposed to cisplatin. At a concentration...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15167899
DOI: 10.1038/sj.cgt.7700724

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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