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Glutathione depletion sensitizes cisplatin- and temozolomide-resistant glioma cells in vitro and in vivo

30 Oct 2014

Abstract excerpt

Malignant glioma is a severe type of brain tumor with a poor prognosis and few options for therapy. The main chemotherapy protocol for this type of tumor is based on temozolomide (TMZ), albeit with limited success. Cisplatin is widely used to treat several types of tumor and, in association with TMZ, is also used to treat recurrent glioma. However, several mechanisms of cellular resistance to cisplatin restrict...

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PMID: 25356874
DOI: 10.1038/cddis.2014.465

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