Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of 5-HT3 receptor mutations identified in schizophrenic patients.

Journal of molecular neuroscience : MN - 1 Jan 2006

Thompson Andrew J, Sullivan Nora L, Lummis Sarah C R

Abstract excerpt

The 5-HT3 receptor is a member of the Cys-loop family of ligand-gated ion channels, proteins that have been implicated in the pathology of several neurological disorders. In this study, we examine two mutations (R344H and P391R) that have been previously identified in individuals diagnosed with s...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Conserved Sequence
Share to Electrophysiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis, Site-Directed

Share to Receptors, Serotonin, 5-HT3

Share to Recombinant Proteins

Share to Schizophrenia

Share to Serotonin

Source

Open in PubMed Open full text

Identifiers

PMID: 17401153
DOI: 10.1385/JMN:30:3:273
PMCID: PMC2649375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17401153-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of 5-HT3 receptor mutations identified in schizophrenic patients.PMID 17401153Read ↗

Pharmacological and electrophysiological properties of the naturally occurring Pro391Arg variant of the human 5-HT3A receptor.Semantic proximity Read ↗

Characterization of the naturally occurring Arg344His variant of the human 5-HT 3A receptor.Semantic proximity Read ↗

Naturally occurring variations in the human 5-HT3A gene profoundly impact 5-HT3 receptor function and expression.Semantic proximity Read ↗

High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor.Semantic proximity Read ↗

Naturally occurring variants in the HTR3B gene significantly alter properties of human heteromeric 5-hydroxytryptamine-3A/B receptorsSemantic proximity Read ↗

Defining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT3 receptor.Semantic proximity Read ↗

Do polymorphisms in the human 5-HT3 genes contribute to pathological phenotypes?Semantic proximity Read ↗

Mutagenesis and molecular modeling reveal the importance of the 5-HT3 receptor F-loop.Semantic proximity Read ↗

A single channel mutation alters agonist efficacy at 5-HT3A and 5-HT3AB receptors.Semantic proximity Read ↗

Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia.Semantic proximity Read ↗

Loop B is a major structural component of the 5-HT3 receptor.Semantic proximity Read ↗

Identification of a domain affecting agonist potency of meta-chlorophenylbiguanide in 5-HT3 receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.