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Article

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency.

The Journal of clinical investigation - 1 Jul 2000

Farooqi I S, Yeo G S, Keogh J M, Aminian S, Jebb S A, Butler G, Cheetham T, O'Rahilly S

Abstract excerpt

Over 20 severely obese subjects in 11 independent kindreds have been reported to have pathogenic heterozygous mutations in the gene encoding the melanocortin 4 receptor (MC4R), making this the most common known monogenic cause of human obesity. To date, the detailed clinical phenotype of this dominantly inherited disorder has not been defined, and no homozygous subjects have been described. We determined the...

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Source

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Identifiers

PMID: 10903343
DOI: 10.1172/JCI9397
PMCID: PMC314308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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