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Article

Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity.

Endocrinology - 1 Jul 2002

Chen Yanyun, Hu Changzhi, Hsu Chiun-Kang, Zhang Qing, Bi Chen, Asnicar Mark, Hsiung Hansen M, Fox Niles, Slieker Lawrence J, Yang Derek D, Heiman Mark L, Shi Yuguang

Abstract excerpt

The hypothalamic neuropeptide melanin-concentrating hormone (MCH) has been implicated in a variety of physiological functions including the regulation of feeding and energy homeostasis. Two MCH receptors (MCHR1 and MCHR2) have been identified so far. To decipher the functional role of the MCH receptors, we have generated and phenotypically characterized mice rendered deficient in MCHR1 expression by homologous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12072376
DOI: 10.1210/endo.143.7.8903

Genes

MCHR1
MCHR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity.PMID 12072376Read ↗

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