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Article

Effects of the lurcher mutation on GluR1 desensitization and activation kinetics.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 May 2004

Klein Rebecca Meier, Howe James R

Abstract excerpt

Previous studies of the lurcher mutation in GluR1 channels concluded that its main effect is to create constitutively active channels (Kohda et al., 2000; Taverna et al., 2000). GluR1Lc channels also exhibit slowed kinetics and a shift in their apparent affinity for glutamate (Kohda et al., 2000; Taverna et al., 2000). Here, we have undertaken a kinetic analysis of GluR1Lc channels to quantify the effects of...

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Identifiers

PMID: 15163686
DOI: 10.1523/JNEUROSCI.0660-04.2004
PMCID: PMC6729373

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Source receipt: pubmed, retrieved 7 Sept 2026.

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