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Article

Death and survival of heterozygous Lurcher Purkinje cells in vitro.

Developmental neurobiology - 1 Jul 2009

Zanjani Hadi S, McFarland Rebecca, Cavelier Pauline, Blokhin Andrei, Gautheron Vanessa, Levenes Carole, Bambrick Linda L, Mariani Jean, Vogel Michael W

Abstract excerpt

The differentiation and survival of heterozygous Lurcher (+/Lc) Purkinje cells in vitro was examined as a model system for studying how chronic ionic stress affects neuronal differentiation and survival. The Lurcher mutation in the delta2 glutamate receptor (GluRdelta2) converts an orphan receptor into a membrane channel that constitutively passes an inward cation current. In the GluRdelta2(+/Lc) mutant, Purkinje...

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Identifiers

PMID: 19294643
DOI: 10.1002/dneu.20715
PMCID: PMC3038214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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