Article
The lurcher mutation and ionotropic glutamate receptors: contributions to programmed neuronal death in vivo.
Brain pathology (Zurich, Switzerland) - 1 Oct 1998
De Jager P L, Heintz N
Abstract excerpt
The recent positional cloning and physiological characterization of the lurcher mutation resulted in the identification of a novel stimulus that results in neurodegeneration. The catastrophic loss of cerebellar Purkinje cells in lurcher heterozygotes has now been strongly associated with a large...
Topics
- Amino Acid Sequence
- Animals
- Apoptosis
- Humans
- Mice
- Mice, Neurologic Mutants
- Molecular Sequence Data
- Mutation
- Receptors, Glutamate