Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chimeric analysis of the site of Lurcher gene action with respect to glial enzyme expression.

Journal of neurogenetics - 1 Apr 1990

Fisher M

Abstract excerpt

Immunocytochemical analysis of aggregation chimeras made using either of the mutants, Lurcher or Purkinje cell degeneration, previously showed that only Bergmann glia close to surviving Purkinje cells expressed an apparently normal level of the enzyme, glycerol-3-phosphate dehydrogenase (GPDH) (Fisher and Mullen, 1988). In the present study, aggregation chimeras were made using embryos from a B6D2 hybrid mouse...

Topics

Alleles
Animals
Cerebellum
Chimera
Glucuronidase
Glycerolphosphate Dehydrogenase
Homozygote
Mice
Mice, Inbred C3H
Mice, Inbred Strains
Mice, Neurologic Mutants
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuroglia

Purkinje Cells

Source

Identifiers

PMID: 2358967
DOI: 10.3109/01677069009107109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2358967-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chimeric analysis of the site of Lurcher gene action with respect to glial enzyme expression.PMID 2358967Read ↗

Bergmann glia require continuous association with Purkinje cells for normal phenotype expression.Semantic proximity Read ↗

Transplanted neurons alter the course of neurodegenerative disease in Lurcher mutant mice.Semantic proximity Read ↗

The lurcher gene induces apoptotic death in cerebellar Purkinje cells.Semantic proximity Read ↗

A relationship between cerebellar Purkinje cells and spatial working memory demonstrated in a lurcher/chimera mouse model system.Semantic proximity Read ↗

Granule cells and cerebellar boundaries: analysis of Unc5h3 mutant chimeras.Semantic proximity Read ↗

Lurcher Purkinje cells express glutamic acid decarboxylase and calbindin mRNAs.Semantic proximity Read ↗

Stunted morphologies of cerebellar Purkinje cells in lurcher and staggerer mice are cell-intrinsic effects of the mutant genes.Semantic proximity Read ↗

The Lurcher cerebellar mutant phenotype is not expressed on a staggerer mutant background.Semantic proximity Read ↗

Ganglioside GD1 alpha in cerebellar Purkinje cells. Its specific absence in mouse mutants with Purkinje cell abnormality and altered immunoreactivity in response to conjunctive stimuli causing long-term desensitization.Semantic proximity Read ↗

Abnormalities in the cerebellar levels of trophic factors BDNF and GDNF in pcd and lurcher cerebellar mutant mice.Semantic proximity Read ↗

Abnormal Purkinje cell dendrites in lurcher chimeric mice result from a deafferentation-induced atrophy.Semantic proximity Read ↗

The community effect and Purkinje cell migration in the cerebellar cortex: analysis of scrambler chimeric mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.