Article
Phenotypic analysis of mice completely lacking netrin 1.
Development (Cambridge, England) - 1 Nov 2015
Yung Andrea R, Nishitani Allison M, Goodrich Lisa V
Abstract excerpt
Netrin 1 (Ntn1) is a multifunctional guidance cue expressed in the ventricular zone and floor plate of the embryonic neural tube. Although Ntn1 is best known for acting as an axon guidance cue through Dcc and neogenin receptors, it is also thought to regulate neuronal survival and blood vessel development through Unc5 family receptors. However, the Ntn1 gene trap mutant mouse does not display all the phenotypes...
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