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Article

Optic nerve damage in mice with a targeted type I collagen mutation.

Investigative ophthalmology & visual science - 1 Jun 2004

Mabuchi Fumihiko, Lindsey James D, Aihara Makoto, Mackey Mason R, Weinreb Robert N

Abstract excerpt

PURPOSE: Transgenic (Col1a1(r/r)) mice gradually develop elevated intraocular pressure (IOP) with open angles. The present study was undertaken to evaluate optic nerve axonal loss with time in these mice. METHODS: The IOP of transgenic (Col1a1(r/r)) mice and control wild-type (Col1a1(+/+)) mice was measured at 7, 12, 16, 24, 36, and 54 weeks of age using a microneedle method. Transgenic Col1a1(r/r) and control...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glaucoma, Open-Angle

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Source

Identifiers

PMID: 15161848
DOI: 10.1167/iovs.03-1008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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