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Article

Optic neuropathy associated with TGFβ dysregulation in mice with a glaucoma-causative mutation of ADAMTS10.

Matrix biology : journal of the International Society for Matrix Biology - 1 Nov 2022

Wu Hang-Jing, Kuchtey Rachel W, Kuchtey John

Abstract excerpt

Glaucoma is a neurodegenerative disease that causes irreversible blindness due to loss of retinal ganglion cells (RGCs) and their axons. We previously identified a G661R mutation of ADAMTS10 (A Disintegrin And Metalloproteinase with ThromboSpondin type 1 motif 10) as the disease-causing mutation in a beagle model of glaucoma. ADAMTS10 is a secreted matrix metalloproteinase that belongs to the ADAMTS family which...

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Identifiers

PMID: 36216203
DOI: 10.1016/j.matbio.2022.10.001
PMCID: PMC10001177

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