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Article

Outflow facility in mice with a targeted type I collagen mutation.

Investigative ophthalmology & visual science - 1 Dec 2009

Dai Yi, Lindsey James D, Duong-Polk Xuandao, Nguyen Duy, Hofer Anthony, Weinreb Robert N

Abstract excerpt

PURPOSE: Transgenic Col1a1(r/r) mice develop elevated intraocular pressure (IOP) with an open angle and progressive optic nerve axon loss. The present study was undertaken to evaluate aqueous outflow facility and its age dependence in these mice. METHODS: Homozygous B6;129S4-Col1a1(tm1Jae) mice and corresponding wild-type Col1a1(+/+) mice from 12 to 56 weeks of age were anesthetized, and IOP was measured with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19797236
DOI: 10.1167/iovs.08-3367
PMCID: PMC6335031

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