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Article

Transgenic Mice Expressing the Tyr437His Mutant of Human Myocilin Protein Develop Glaucoma

24 Apr 2008

Abstract excerpt

PURPOSE: To developed a genetic mouse model of primary open-angle glaucoma induced by expression of mutated human myocilin in transgenic mice and to test whether expression of mutated human myocilin in the eye angle structures produces more significant damage to the eye than does mutated mouse myocilin. METHODS: Recombineering in Escherichia coli was used to introduce the Tyr437His point mutation into a BAC...

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PMID: 18436825
DOI: 10.1167/iovs.07-1339

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