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The Arg972 variant in insulin receptor substrate-1 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.

Diabetes care - 1 Jun 2004

Sesti Giorgio, Marini Maria Alelaide, Cardellini Marina, Sciacqua Angela, Frontoni Simona, Andreozzi Francesco, Irace Concetta, Lauro Davide, Gnasso Agostino, Federici Massimo, Perticone Francesco, Lauro Renato

Abstract excerpt

OBJECTIVE: The aim of this study was to investigate whether diabetic patients carrying the Arg(972) insulin receptor substrate-1 (IRS-1) variant are at increased risk for secondary failure to sulfonylurea. RESEARCH DESIGN AND METHODS: A total of 477 unrelated Caucasian type 2 diabetic patients were recruited according to the following criteria: onset of diabetes after age 35 years, absence of ketonuria at...

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Identifiers

PMID: 15161794
DOI: 10.2337/diacare.27.6.1394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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