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Article

Pharmacogenetics of oral antidiabetes drugs: evidence for diverse signals at the IRS1 locus.

The pharmacogenomics journal - 22 May 2018

Prudente S, Di Paola R, Pezzilli S, Garofolo M, Lamacchia O, Filardi T, Mannino G C, Mercuri L, Alberico F, Scarale M G, Sesti G, Morano S, Penno G, Cignarelli M, Copetti M, Trischitta V

Abstract excerpt

To investigate the role of IRS1 locus on failure to oral antidiabetes drugs (OADs) we genotyped single-nucleotide polymorphisms (SNPs), rs2943641, rs7578326 (tagging all SNPs genome-wide associated with type 2 diabetes (T2D) and related traits at this locus) and rs1801278 (that is, the loss-of-function IRS1 G972R amino acid substitution) in 2662 patients with T2D. Although no association with OAD failure was...

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Share to Administration, Oral
Share to Blood Glucose
Share to Diabetes Mellitus, Type 2
Share to Hypoglycemic Agents
Share to Insulin Receptor Substrate Proteins
Share to Metformin
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Share to White People

Source

Identifiers

PMID: 28696414
DOI: 10.1038/tpj.2017.32

Genes

IRS1

Variants

rs2943641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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