Article
The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.
The Journal of clinical endocrinology and metabolism - 1 Jun 2006
Sesti Giorgio, Laratta Emanuela, Cardellini Marina, Andreozzi Francesco, Del Guerra Silvia, Irace Concetta, Gnasso Agostino, Grupillo Maria, Lauro Renato, Hribal Marta Letizia, Perticone Francesco, Marchetti Piero
Abstract excerpt
CONTEXT: Several studies suggest that genetic factors may play a role in the different responses to antidiabetic therapy; however, conclusive evidence is still lacking. OBJECTIVE: The objective of the study was to investigate whether diabetic patients carrying the E23K variant in KCNJ11 are at increased risk for secondary sulfonylurea failure. DESIGN: Secondary sulfonylurea failure was defined as fasting plasma...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.