Article
Exon 15 BRAF mutations are uncommon in melanomas arising in nonsun-exposed sites.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2004
Cohen Yoram, Rosenbaum Eli, Begum Shahnaz, Goldenberg David, Esche Clemens, Lavie Ofer, Sidransky David, Westra William H
Abstract excerpt
PURPOSE: An activating point mutation of the BRAF oncogene has been identified in a high proportion of cutaneous nevi and cutaneous melanomas, but its frequency in melanomas arising from the mucosa of head and neck is unknown. EXPERIMENTAL DESIGN: We tested 17 malignant mucosal melanomas of the head and neck for the thymine (T)-->adenine (A) missense mutation at nucleotide 1796 in the BRAF gene using direct...
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