Article
Exon 15 BRAF mutations are uncommon in canine oral malignant melanomas.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 2005
Shelly Suzanne, Chien May B, Yip Becky, Kent Michael S, Theon Alain P, McCallan Jennifer L, London Cheryl A
Abstract excerpt
An activating mutation in codon 599 of BRAF has been identified in approximately 60% of human cutaneous nevi and melanomas, but not melanomas of mucosal origin. The purpose of this study was to determine if BRAF mutations occur in canine oral malignant melanomas. The canine BRAF gene was first cloned from normal canine testicular cDNA, and a novel previously unreported splice variant involving exon 5 was...
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