Article
BRAF exon 15 T1799A mutation is common in melanocytic nevi, but less prevalent in cutaneous malignant melanoma, in Chinese Han.
The Journal of investigative dermatology - 1 May 2011
Qi Rui-Qun, He Li, Zheng Song, Hong Yuxiao, Ma Lei, Zhang Shifa, Zhao Liping, Guo Xinjian, Wang Yong, Yu Jiang-Yun, Fu Lan, Zhang Wei, Long Tingfeng, Zhang Chao, Chen Guohong, Lin Junping, Wang Chengliang, Zhou Li, Mi Qingsheng, Weiland Matthew, Chen John Z S, McHenga S S Salum, Wang Ya-Kun, McHepange Uwesu, Wang Zhimin, Chen Hong-Duo, Gao Xing-Hua
Abstract excerpt
Frequent somatic mutations of BRAF (v-raf murine sarcoma viral oncogene homolog B) exon T1799A, which are implicated in the initial events of promutagenic cellular proliferation, are detected in both malignant melanomas (MM) and melanocytic nevi (MN). Most of the data regarding BRAF exon T1799A mutation have been from Caucasian cohorts, and a comprehensive screening of a homogeneous population is lacking. A total...
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