Article
Distribution of BRAF T1799A(V600E) mutations across various types of benign nevi: implications for melanocytic tumorigenesis.
The American Journal of dermatopathology - 1 Dec 2007
Wu Julie, Rosenbaum Eli, Begum Shanaz, Westra William H
Abstract excerpt
PURPOSE: The BRAF mutation is common in melanomas, but variation in rates across melanoma subtypes points to a complex interplay between BRAF activation and other factors (eg, sun exposure). Nevi also harbor the BRAF mutation. A description of mutation distribution in nevi could provide insight into the significance of this event in melanocytic tumorigenesis. EXPERIMENTAL DESIGN: One hundred thirty-five nevi from...
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