Article
Absence of BRAF mutations in UV-protected mucosal melanomas.
Journal of medical genetics - 1 Apr 2004
Edwards R H, Ward M R, Wu H, Medina C A, Brose M S, Volpe P, Nussen-Lee S, Haupt H M, Martin A M, Herlyn M, Lessin S R, Weber B L
Abstract excerpt
BACKGROUND: Mutations in BRAF have recently been identified in a significant percentage of primary and metastatic cutaneous malignant melanomas. As ultraviolet (UV) exposure may play a role in the development of cutaneous melanoma lesions with BRAF mutations, BRAF mutation frequency in melanomas...
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