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Article

Incidence of BRAF oncogene mutation and clinical relevance for primary cutaneous melanomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2004

Shinozaki Masaru, Fujimoto Akihide, Morton Donald L, Hoon Dave S B

Abstract excerpt

PURPOSE: The purpose of the study was to clarify the incidence of B-raf oncogene (BRAF) mutations in primary cutaneous melanomas, their relation to tumor progression, and effect on disease outcome. Somatic mutations of BRAF kinase, a component of the Ras-mitogen-activated protein/extracellular signal-regulated kinase kinase-mitogen-activated protein kinase pathway, are frequently reported (>65%) in nevi and...

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Source

Identifiers

PMID: 15014028
DOI: 10.1158/1078-0432.ccr-1169-3

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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