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Article

Determinants of BRAF mutations in primary melanomas.

Journal of the National Cancer Institute - 17 Dec 2003

Maldonado Janet L, Fridlyand Jane, Patel Hetal, Jain Ajay N, Busam Klaus, Kageshita Toshiro, Ono Tomomichi, Albertson Donna G, Pinkel Dan, Bastian Boris C

Abstract excerpt

The RAS/mitogen-activated protein kinase pathway sends external growth-promoting signals to the nucleus. BRAF, a critical serine/threonine kinase in this pathway, is frequently activated by somatic mutation in melanoma. Using a cohort of 115 patients with primary invasive melanomas, we show that BRAF mutations are statistically significantly more common in melanomas occurring on skin subject to intermittent sun...

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Identifiers

PMID: 14679157
DOI: 10.1093/jnci/djg123

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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