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Article

The oncogenic B-raf V599E mutation occurs more frequently in melanomas at sun-protected body sites.

International journal of oncology - 1 Jul 2006

Deichmann Martin, Krahl Dieter, Thome Marianne, Wüst Kirsten, Hassanzadeh Judith, Helmke Burkhard

Abstract excerpt

Downstream of Ras, the serine/threonine kinase, B-raf, has recently been reported to be mutated, among other carcinomas, in a substantial subset of primary melanomas with a preponderance of the oncogenic V599E transition. As the risk of melanoma is enhanced by intermittent ultraviolet (UV) exposure but is less with chronic UV exposure, we here studied B-raf kinase domain (exon 15) mutations in primary cutaneous...

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PMID: 16773193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The oncogenic B-raf V599E mutation occurs more frequently in melanomas at sun-protected body sites.PMID 16773193Read ↗

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