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Article

The APOE genotype: modification of therapeutic responses in Alzheimer's disease.

Current pharmaceutical design - 1 Jan 2015

Hanson Angela J, Craft Suzanne, Banks William A

Abstract excerpt

The translation of promising preclinical treatments into effective drugs for Alzheimer's disease (AD) has been challenging. One of the most potent risk factors for sporadic AD is carrier status of the epsilon 4 allele of the apolipoprotein E gene (E4). E4 carriers show a differential response to several therapies which are being investigated as AD treatments, including acetylcholinesterase inhibitors and...

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Source

Identifiers

PMID: 25330331
DOI: 10.2174/1381612820666141020164222

Genes

APOE

Provenance

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