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Article

A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL.

Journal of lipid research - 1 Jul 2018

Cooke Allison L, Morris Jamie, Melchior John T, Street Scott E, Jerome W Gray, Huang Rong, Herr Andrew B, Smith Loren E, Segrest Jere P, Remaley Alan T, Shah Amy S, Thompson Thomas B, Davidson W Sean

Abstract excerpt

APOA1 is the most abundant protein in HDL. It modulates interactions that affect HDL's cardioprotective functions, in part via its activation of the enzyme, LCAT. On nascent discoidal HDL, APOA1 comprises 10 α-helical repeats arranged in an anti-parallel stacked-ring structure that encapsulates a lipid bilayer. Previous chemical cross-linking studies suggested that these APOA1 rings can adopt at least two...

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Topics

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Share to Apolipoprotein A-I
Share to Cholesterol, HDL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to APOA1 gene

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Share to Phosphatidylcholine-Sterol O-Acyltransferase

Source

Open in PubMed Open full text

Identifiers

PMID: 29773713
DOI: 10.1194/jlr.M085332
PMCID: PMC6027914

Genes

APOA1
LCAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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