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Article

Geographical and Temporal Conservation of Antibody Recognition of Plasmodium falciparum Variant Surface Antigens

20 May 2004

Abstract excerpt

The slow acquisition of protection against Plasmodium falciparum malaria probably reflects the extensive diversity of important antigens. The variant surface antigens (VSA) that mediate parasite adhesion to a range of host molecules are regarded as important targets of acquired protective immunity, but their diversity makes them questionable vaccine candidates. We determined levels of VSA-specific immunoglobulin...

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PMID: 15155661
DOI: 10.1128/iai.72.6.3531-3535.2004

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