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Article

Human pregnancy‐associated malaria‐specific B cells target polymorphic, conformational epitopes in VAR2CSA

3 Nov 2006

Abstract excerpt

Pregnancy-associated malaria (PAM) is caused by Plasmodium falciparum-infected erythrocytes (IEs) that bind to chondroitin sulphate A (CSA) in the placenta by PAM-associated clonally variant surface antigens (VSA). Pregnancy-specific VSA (VSA(PAM)), which include the PfEMP1 variant VAR2CSA, are targets of IgG-mediated protective immunity to PAM. Here, we report an investigation of the specificity of naturally...

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PMID: 17176260
DOI: 10.1111/j.1365-2958.2006.05503.x

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Human pregnancy‐associated malaria‐specific B cells target polymorphic, conformational epitopes in VAR2CSAPMID 17176260Read ↗

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