Protection against Clinical Malaria by Heterologous Immunoglobulin G Antibodies against Malaria‐Infected Erythrocyte Variant Surface Antigens Requires Interaction with Asymptomatic Infections

Abstract excerpt

Erythrocytes infected with mature stages of Plasmodium falciparum express variant surface antigens (VSAs) of parasite origin, including P. falciparum erythrocyte membrane protein 1. Anti-VSA antibodies protect against clinical malaria caused by parasites bearing VSAs to which they are specific (homologous), but their role in protecting against heterologous infection is unclear. Here, we report that, among 256...

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