Article
Variant-specific antibodies to merozoite surface protein 2 and clinical expression of Plasmodium falciparum malaria in rural Amazonians.
The American journal of tropical medicine and hygiene - 1 Jun 2007
Scopel Kézia K G, da Silva-Nunes Mônica, Malafronte Rosely S, Braga Erika M, Ferreira Marcelo U
Abstract excerpt
Naturally acquired antibodies to five variants of the merozoite surface protein 2 (MSP-2), a target of clinical immunity to Plasmodium falciparum malaria, were measured in a cohort of rural Amazonians. Local MSP-2 variants comprised both highly divergent families of alleles (FC27 and 3D7). Total IgG antibodies to two FC27-type antigens were found in 22-28% of subjects at baseline, with substantial...
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