Article
Antigenic polymorphism and naturally acquired antibodies to Plasmodium vivax merozoite surface protein 1 in rural Amazonians.
Clinical and vaccine immunology : CVI - 1 Oct 2007
Bastos Melissa S, da Silva-Nunes Mônica, Malafronte Rosely S, Hoffmann Erika Hellena E, Wunderlich Gerhard, Moraes Sandra L, Ferreira Marcelo U
Abstract excerpt
Merozoite surface protein 1 of Plasmodium vivax (PvMSP-1), a major target for malaria vaccine development, contains six highly polymorphic domains interspersed with conserved sequences. Although there is evidence that the sequence divergence in PvMSP-1 has been maintained over 5 million years by balanced selection exerted by the host's acquired immunity, the variant specificity of naturally acquired antibodies to...
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