Mechanism of action at the molecular level of the antiviral drug 3(2H)-isoflavene against type 2 poliovirus.

doi:10.1128/AAC.48.6.2233-2243.2004

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Article

Mechanism of action at the molecular level of the antiviral drug 3(2H)-isoflavene against type 2 poliovirus.

Antimicrobial agents and chemotherapy - 1 Jun 2004

Salvati Anna L, De Dominicis Alessandra, Tait Sabrina, Canitano Andrea, Lahm Armin, Fiore Lucia

Abstract excerpt

The mechanism of action of the antiviral compound 3(2H)-isoflavene against Sabin type 2 poliovirus has been studied, and interference with virus uncoating was demonstrated. Isolation and sequencing of drug-resistant variants revealed single amino acid substitutions (I194M or D131V) in the VP1 capsid protein. While M194 is located in a hydrophobic pocket and should partially fill the space occupied by the...

Topics

Algorithms
Antiviral Agents
Capsid
Capsid Proteins
Centrifugation, Density Gradient
Drug Resistance, Viral
HeLa Cells
Hot Temperature
Humans
Isoflavones
Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenotype

Poliovirus

RNA, Viral

Recombinant Proteins

Transfection

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 15155227
DOI: 10.1128/AAC.48.6.2233-2243.2004
PMCID: PMC415587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15155227-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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