Characterization of susceptibility variants of poliovirus grown in the presence of favipiravir.

doi:10.1016/j.jmii.2017.03.004

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Article

Characterization of susceptibility variants of poliovirus grown in the presence of favipiravir.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi - 1 Oct 2018

Daikoku Tohru, Mizuguchi Mineyuki, Obita Takayuki, Yokoyama Takeshi, Yoshida Yoshihiro, Takemoto Masaya, Shiraki Kimiyasu

Abstract excerpt

BACKGROUND: T-705 (favipiravir) is a potent inhibitor of RNA-dependent RNA polymerases of influenza viruses and no favipiravir-resistant virus has been isolated. Poliovirus RNA polymerase has been well characterized and isolation of resistant virus was examined in poliovirus. METHODS: Susceptibil...

Topics

Amides
Animals
Antiviral Agents
Chlorocebus aethiops
Drug Resistance, Viral
Models, Molecular
Mutation
Poliovirus
Protein Binding
Pyrazines
RNA-Dependent RNA Polymerase
Vero Cells
Viral Proteins
Virus Replication

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Open in PubMed

Identifiers

PMID: 28709841
DOI: 10.1016/j.jmii.2017.03.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-28709841-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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