Isolation and biological characterization of 3(2H)-isoflavene-resistant and -dependent poliovirus type 2 Sabin mutants.

doi:10.1099/0022-1317-80-1-157

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Article

Isolation and biological characterization of 3(2H)-isoflavene-resistant and -dependent poliovirus type 2 Sabin mutants.

The Journal of general virology - 1 Jan 1999

Genovese D, Catone S, Farah M E, Gambacorta A, Fiore L

Abstract excerpt

Poliovirus type 2 Sabin mutants were selected for drug resistance and dependence by plating on HeLa cell monolayers in the presence of 3(2H)-isoflavene, a compound related to dichloroflavan, which prevents the shut-off of host translation and poliovirus RNA and protein synthesis. The drug-resistant mutants grew equally well in the presence and in the absence of the drug, while the drug-dependent mutants only grew...

Topics

Antiviral Agents
Centrifugation, Density Gradient
Cross Reactions
Drug Resistance, Microbial
HeLa Cells
Heating
Humans
Isoflavones
Mutation
Poliovirus
Poliovirus Vaccine, Oral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Biosynthesis

RNA, Viral

Sucrose

Temperature

Transfection

Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 9934698
DOI: 10.1099/0022-1317-80-1-157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9934698-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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