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Article

Characterization of Poliovirus Neutralization Escape Mutants of Single-Domain Antibody Fragments (VHHs).

Antimicrobial agents and chemotherapy - 1 Aug 2015

Schotte Lise, Thys Bert, Strauss Mike, Filman David J, Rombaut Bart, Hogle James M

Abstract excerpt

To complete the eradication of poliovirus and to protect unvaccinated people subsequently, the development of one or more antiviral drugs will be necessary. A set of five single-domain antibody fragments (variable parts of the heavy chain of a heavy-chain antibody [VHHs]) with an in vitro neutralizing activity against poliovirus type 1 was developed previously (B. Thys, L. Schotte, S. Muyldermans, U. Wernery, G....

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Identifiers

PMID: 26014941
DOI: 10.1128/AAC.00878-15
PMCID: PMC4505203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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