Article
Characterization of Poliovirus Neutralization Escape Mutants of Single-Domain Antibody Fragments (VHHs).
Antimicrobial agents and chemotherapy - 1 Aug 2015
Schotte Lise, Thys Bert, Strauss Mike, Filman David J, Rombaut Bart, Hogle James M
Abstract excerpt
To complete the eradication of poliovirus and to protect unvaccinated people subsequently, the development of one or more antiviral drugs will be necessary. A set of five single-domain antibody fragments (variable parts of the heavy chain of a heavy-chain antibody [VHHs]) with an in vitro neutral...
Topics
- Amino Acid Substitution
- Antibodies, Neutralizing
- Antiviral Agents
- Binding Sites
- Capsid Proteins
- Cell Line, Tumor
- HeLa Cells
- Humans
- Immunoglobulin Fragments
- Mutation
- Poliovirus
- Viral Proteins