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Article

Mechanism of action of a pestivirus antiviral compound.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2000

Baginski S G, Pevear D C, Seipel M, Sun S C, Benetatos C A, Chunduru S K, Rice C M, Collett M S

Abstract excerpt

We report here the discovery of a small molecule inhibitor of pestivirus replication. The compound, designated VP32947, inhibits the replication of bovine viral diarrhea virus (BVDV) in cell culture at a 50% inhibitory concentration of approximately 20 nM. VP32947 inhibits both cytopathic and noncytopathic pestiviruses, including isolates of BVDV-1, BVDV-2, border disease virus, and classical swine fever virus....

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Identifiers

PMID: 10869440
DOI: 10.1073/pnas.140220397
PMCID: PMC16656

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