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Broad-spectrum antiviral ferruginol analog affects the viral proteins translation and actin remodeling during dengue virus infection

4 Mar 2025

Abstract excerpt

Dengue virus infection is the most important arbovirosis around the world. To date, no antiviral drugs have been approved for its treatment. Host-targeted antivirals (HTA) have emerged as a promising strategy, because of their high barrier to resistance. Using plaque-forming unit assays, molecular docking, fluorescence microscopy, image analysis, and molecular/cellular assays, it was found that...

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PMID: 40043781
DOI: 10.1016/j.antiviral.2025.106139

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