Article
Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Sept 2012
Brehm Jessica H, Koontz Dianna L, Wallis Carole L, Shutt Kathleen A, Sanne Ian, Wood Robin, McIntyre James A, Stevens Wendy S, Sluis-Cremer Nicolas, Mellors John W
Abstract excerpt
BACKGROUND: It is not known how often mutations in the connection and ribonuclease H domains of reverse transcriptase (RT) emerge with failure of first-line antiretroviral therapy (ART) in subtype C human immunodeficiency virus type 1 (HIV-1) infection and how these mutations affect susceptibility to other antiretrovirals. METHODS: We compared full-length RT sequences in plasma obtained before therapy and at...
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