Article
Impact of nelfinavir resistance mutations on in vitro phenotype, fitness, and replication capacity of human immunodeficiency virus type 1 with subtype B and C proteases.
Antimicrobial agents and chemotherapy - 1 Sept 2004
Gonzalez Luis M F, Brindeiro Rodrigo M, Aguiar Renato S, Pereira Helena S, Abreu Celina M, Soares Marcelo A, Tanuri Amilcar
Abstract excerpt
Human immunodeficiency virus type 1 subtype B and C proteases were manipulated to contain 90M, 88D, or 89L, and their in vitro biological properties were studied. We showed that D30N has significantly more impact in subtype C than in subtype B counterparts, accounting for the reported low prevale...
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