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Article

In vitro hypersusceptibility of human immunodeficiency virus type 1 subtype C protease to lopinavir.

Antimicrobial agents and chemotherapy - 1 Sept 2003

Gonzalez Luis M F, Brindeiro Rodrigo M, Tarin Michelle, Calazans Alexandre, Soares Marcelo A, Cassol Sharon, Tanuri Amilcar

Abstract excerpt

In order to characterize the impact of genetic polymorphisms on the susceptibility of subtype C strains of human immunodeficiency virus type 1 to protease inhibitors (PIs), a subtype B protease that originated from an infectious clone was modified through site-directed mutagenesis to include the...

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Identifiers

PMID: 12936979
DOI: 10.1128/AAC.47.9.2817-2822.2003
PMCID: PMC182615

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12936979-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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