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Article

Immunological cross-reactivity against a drug mutated HIV-1 protease epitope after DNA multi-CTL epitope construct immunization.

Vaccine - 22 May 2006

Boberg Andreas, Sjöstrand Dan, Rollman Erik, Hinkula Jorma, Zuber Bartek, Wahren Britta

Abstract excerpt

Epitopes in HIV polymerase were analyzed by peptide binding to human leukocyte antigen (HLA) A0201 molecules, the most frequent HLA class in the Caucasian population. We found that HIV-1 protease peptides representing both the wild type and anticipated drug resistance variants of the sequence bound well to HLA-A0201. We also found that wild type as well as a double mutated variant of the epitope was strongly...

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Share to Cross Reactions
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Share to HIV Envelope Protein gp120

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16181710
DOI: 10.1016/j.vaccine.2005.08.019

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