Article
Induction of T-cell immunity to antiretroviral drug-resistant human immunodeficiency virus type 1.
Journal of virology - 1 Jun 2005
Stratov Ivan, Dale C Jane, Chea Socheata, McCluskey James, Kent Stephen J
Abstract excerpt
Antiretroviral drug-resistant human immunodeficiency virus type 1 (HIV-1) is a major, growing, public health problem. Immune responses targeting epitopes spanning drug resistance sites could ameliorate development of drug resistance. We studied 25 individuals harboring multidrug-resistant HIV-1 for T-cell immunity to HIV-1 proteins and peptides spanning all common drug resistance mutations. CD8 T cells targeting...
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