Article
Expression of a dominant negative heat shock factor-1 construct inhibits aneuploidy in prostate carcinoma cells.
The Journal of biological chemistry - 30 Jul 2004
Wang Yiqun, Theriault Jimmy R, He Haiying, Gong Jianlin, Calderwood Stuart K
Abstract excerpt
Recent studies have implicated heat shock proteins (HSP) and heat shock transcription factor 1 (HSF1) in tumor progression. We have examined the role of HSF1 in the malignant phenotype of PC-3 prostate carcinoma cells. We have developed a dominant negative construct of HSF1 that antagonizes transcription from HSP promoters and results in the depletion of intracellular HSP 70. Our studies indicate that expression...
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