Article
Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis.
The Journal of biological chemistry - 27 Mar 1998
McMillan D R, Xiao X, Shao L, Graves K, Benjamin I J
Abstract excerpt
Heat shock transcription factor 1 (HSF1) is a member of the vertebrate HSF family that regulates stress-inducible synthesis of heat shock proteins (HSPs). Although the synthesis of the constitutively expressed and inducible members of the heat shock family of stress proteins correlates with incre...
Topics
- Alleles
- Animals
- Apoptosis
- Base Sequence
- Cells, Cultured
- DNA-Binding Proteins
- Fluorescence
- Genotype
- Heat Shock Transcription Factors
- Heat-Shock Proteins
- Hot Temperature
- Mice
- Mice, Inbred BALB C
- Microscopy, Confocal
- Molecular Sequence Data
- RNA, Messenger
- Transcription Factors