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Article

Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis.

The Journal of biological chemistry - 27 Mar 1998

McMillan D R, Xiao X, Shao L, Graves K, Benjamin I J

Abstract excerpt

Heat shock transcription factor 1 (HSF1) is a member of the vertebrate HSF family that regulates stress-inducible synthesis of heat shock proteins (HSPs). Although the synthesis of the constitutively expressed and inducible members of the heat shock family of stress proteins correlates with increased cellular protection, their relative contributions in acquired cellular resistance or "thermotolerance" in...

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Identifiers

PMID: 9516453
DOI: 10.1074/jbc.273.13.7523

Genes

HSF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis.PMID 9516453Read ↗

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Heat shock factor 1-mediated thermotolerance prevents cell death and results in G2/M cell cycle arrest.Semantic proximity Read ↗

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Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.Semantic proximity Read ↗

Disruption of Heat Shock Factor 1 Reveals an Essential Role in the Ubiquitin Proteolytic PathwaySemantic proximity Read ↗

Multiple functions of Drosophila heat shock transcription factor in vivo.Semantic proximity Read ↗

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