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Article

HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells.

The EMBO journal - 16 Oct 2014

Donnelly Neysan, Passerini Verena, Dürrbaum Milena, Stingele Silvia, Storchová Zuzana

Abstract excerpt

Aneuploidy is a hallmark of cancer and is associated with malignancy and poor prognosis. Recent studies have revealed that aneuploidy inhibits proliferation, causes distinct alterations in the transcriptome and proteome and disturbs cellular proteostasis. However, the molecular mechanisms underlying the changes in gene expression and the impairment of proteostasis are not understood. Here, we report that human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25205676
DOI: 10.15252/embj.201488648
PMCID: PMC4253526

Genes

HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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